What covid19, chickens and dioxin have in common? And what is digoxin?

Updates first, the main post is behind the divider bar.. Thank you!

Updarte 1st Feb 2024: Addition about spectroscopy properties of riboflavin, known since way before 1957, in the middle of the post…

Update 3/14/2023 In this global accumulation of bad news,this one gives me hope:

Business Podcast | DR. BRYAN ARDIS | TURNING BADNESS INTO BETTERNESS, HEALTH AND WELLNESS

Update 3/8/2023: It is astonishing how “AGENDA 2030 – Dutch Farmers, Train Derailments, and EPA Land Grabs” at

AGENDA 2030 – Dutch Farmers, Train Derailments, and EPA Land Grabs

can connect to these small molecules out there described in this post. All carefully planned AND PRODUCED by the chemical (Rockefeller et al.) industry..

Update 3/1/2023 : Help with liver, to detoxify all chemicals.., right now in a series available at https://stopfattyliver.com/2-hl/

Update 28-2-2032 (!): DIGOXIN and HIV-1 addition, at the end of the post.

Update 27/8/2023: Another HUGE TRAGEDY, this time in Lahaina on MAUI (HI), reason ? ‘climate change’.. goal? HUMAN ANNIHILATION following LAND GRAB. All available at: https://www.thelastamericanvagabond.com/maui-land-grabs-space-force-dew/ Every single of these events end up with LARGER environmental pollution, being then a pre-text for many changes affecting human life.

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Long time no hear, Dear Readers. Sorry, the cold dark winter makes some of us asleep. Don’t worry, this post will be short, just pointing to some ‘common grounds’ in the troubled times we got.

We’ve heard for the last >2 years a lot about covid19 drugs like Remdesivir (PubChem source):

about universal synthetic genetic parts injected in ‘emergency’ across the entire globe^1:

less about ivermectin (wiki source..) :

and possibly nothing about yet another potential covid cure and so much more, the vitamin B2, also called riboflavin, with photosensitizing properties. The amazing scientist Albert Szent-Gyorgyi wrote a book among others about it in 1957(!!) and its title was ‘BIOENERGETICS’. I got its WITHDRAWN version from Trinity College… What was so amazing about that essential VITAMIN B2, that the tinniest addition of the agent called 2,4D (growth hormone, the one used in wars, agriculture, etc) to a solution with riboflavin appears to ‘quench’ its fluorescence and phosphorescence. Colors of the solution changed, the singlet→triplet transition states became totally disturbed, indicating also a change in their lifetime. The same 2,4D causes also a muscle disease called myotonia, in which repetitive response of nerve end plates of muscles causes their multiple depolaisation, instead of one…. That process affects CO2 production by the animals injected with it! The more 2,4D injected into the animals, the stronger the myotomic symptoms, the less CO2 produced, with DEATH following the ~200-300mg/kg of body mass)… Back to its connection with covid19.

In the molecular docking experiments described at:

https://covid.us.org/2020/05/31/riboflavin-vitamin-b2-as-an-inhibitor-of-covid-19/

one of the modeling studies found out, that riboflavin compares 100% with remdesivir during inhibition of Mpro and RdRp, parts of the SARS-CoV-2 virus. The docking scores for binding of the viral enemy (RdRp i.e. RNA dependent RNA polymerase in particular) were as follows:

Riboflavin -7.90 -9.00

Remdesivir -8.10 -9.00
Nelfinavir -7.90 -9.30
Lopinavir -7.90 -9.70

indicating, that riboflavin has the same potential as the ‘main official allowable’ Fauci’s and Gilead’s drug, Remdesivir. The analysis of 15 studies ended with the following review, quote:”The first seven studies above, plus the 12th, 13th, and 14th, found that riboflavin (vitamin B2) is an effective inhibitor of SARS-CoV-2, the virus that causes Covid-19. Then studies 8, 9, 10, and 11 found that FAD is an inhibitor of the same virus, while studies 8 and 11 also found that FMN is an inhibitor. The targets inhibited by these three related compounds include both viral proteases, the Spike protein, helicase, replicase, the N-protein, and Nsp15 and 16. That is a broad range of activity against this virus. And the binding affinity found by these studies ranged from moderate to very strong.”

The yellow color of egg yolks is partly thanks to riboflavin, without which there would not be any chicken out there on this planet, literally^2. And no rats either, according to knowledge gained as far back as 1943 ^2a. Given, that the topic of eggs became very popular in particular in regard to covid and food crisis:

Eggs, Spike Proteins, And The Manufactured Food Crisis

the question is, what makes the riboflavin 3D structure, shown below, so special??

Strangely even NIH has a nice section on the vitamin B2, one of the essential energy sources:

https://ods.od.nih.gov/factsheets/Riboflavin-HealthProfessional/

The next crisis, environmental disaster in Ohio is connected with this structure, dioxin family of chemical compounds (PubChem 2,3,7,8-Tetrachlorodibenzo-p-dioxin also known as TCDD) :

TCDD has the ability to induce the expression of specific genetic elements like miRNA-25 and miRNA-92^11. How important that is, tells us a quote from ^11: “Both miR-92 and miR-25 target the p53 gene (Gordon et al., 2014). Interestingly, TCDD has been recently shown to suppress p53 expression (Reyes-Hernández et al.,
2010; Ambolet-Camoit et al., 2010)”. That in turn results in all sorts of cancers. On top of it, quote “Interestingly, dioxin has been recently shown to modulate
autophagy (Fiorito et al., 2011) and, hence, alteration of miR-25 levels represents a means by which dioxin can mediate apoptosis and cell cycling processes (Wang et al., 2014).“ The references in the quotes can be found in the ^11.

Thus the for long time known cancerous properties of dioxins are in that respect, overlapping quite well with the ‘side effects’ of covid genetically modifying injections.

The biomarkers for an exposure to dioxin-related compounds are the changing levels of cytochrome P450, Superoxide dismutase, DT-diaphorase, and the egg shell thinning effect, among others. All three enzymes have functions connected with the presence of flavin molecules, possibly mimicked and thus affected by the ‘similar looking’ dioxin. The never-ending efforts of the chemical/pharma industry to mimick natural ingredients with synthetics is like the apparent clones of certain important humans, for the achievement of certain goals. Seldom good ones..

Clear common ground for all the above are the aromatic rings sharing their electrons above and below each of these hexagonal surfaces. And when looking at the planar structure of graphene (rotated by PubChem to add to the spacial confusion…):

one has the feeling, that one, the graphene, would catch all of the above, like a fishing net.. No wonder we find publications like this one^3 describing the wonderful properties of graphene sensing the dioxin. These ‘wonderful’ properties do not apply to the human body though, which does not want to be caught like a fish…

Looking at this scheme overlapping the graphene and dioxin molecules in one direction, from this publication^3:

one should expect even a 100% efficient filtering properties of dioxin by this ‘wonder’ material. And NO, definitely no filtration of CO2, as suggested by phys.org at https://phys.org/news/2020-03-low-cost-graphene-iron-filters-gaseous-mixtures.html but rather filtration of that, what is really dangerous!

An extensive 2018 Nature review^4 titled “Principles for targeting RNA with drug-like small molecules“ mentions quote: riboflavin riboswitches, which function as RNA-mediated regulators of gene expression in bacteria. Well, eukaryotes, including us humans, do have also riboswitches, which control the overall gene expression^5. The ^4 describes riboflavin, Vitamin B2, as a ‘drug-like RNA-targeting molecule’ together with linezolid, ribocil, patented drugs. Here is the bonding scheme of how RNA and proteins ‘recognize’ the riboflavin:

The dioxin, similarly to riboflavin^6, binds to DNA/RNA, a good estimation of which was made in ^7. So do we have anywhere any connection between riboflavin and dioxin? Was able to find only 2 sources, which show that yes, there are some common grounds, for example in: -”Riboflavin Photosensitized Oxidation of 2,4-Dichlorophenol: Assessment of Possible Chlorinated Dioxin Formation”^8

-”A metabolite of riboflavin binds to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor”^9

Looking years back, the riboflavin issue was always there, even with the first determination of the Riboflavin Binding Protein structure, which was published in 1997^10, but never deposited in the PDB data bank.. One would need to ask, WHY?

Every structural ring shown here has that one important feature, the ‘free electrons’ moving around that one plane, absorb light. Thus the war on words in these troubled times, turned into the war on light, by filling out our living spaces with molecular mimick absorbing that good (SUN:) light… And maybe to all the good substack posts suggesting some remedies for covid, dioxins, etc. we could add that riboflavin (Vit B2) too???

Few very good posts describing natural ingredients, a proven nutritional support during dioxin exposure, the best in my opinion:

Glyphosate and Dioxin Detox

and more

Ways to mitigate dioxin damage

Mike Adams from Natural News suggests taking I3C, lot of phenol compounds from all different plants in order to detoxify dioxin. One of the best science resources on how the I3C compound functions in multiple pathways related to cancers, including involvement in protection during dioxin exposure can be found at: https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/indole-3-carbinol

Given the mimick of all the chemical synthetic compounds of the dioxin poisoning, one could imagine that any good NATURAL ingredient similar to the synthetics, recognized by the body as natural, including any fulvic acid derivatives, could be of hopeful use. There is also one japanese patent at https://patents.google.com/patent/JP4100623B2/en mentioning the precious compound derived from green tea (camelia sinensis) with this structure (from https://pubchem.ncbi.nlm.nih.gov/compound/Epigallocatechin-gallate#section=3D-Conformer ):

and also variety of other plants (black beans, licorice, flower extracts, red ginseng), all affecting dioxin circulating in the test animals bodies. Another japanese patent titled “An anti-dioxin health food extracted from fermented soybeans and containing genistein as a main ingredient.“ (https://patents.google.com/patent/JP3482558B2/en) speaks for itself in terms of how the genitstein compound works

:

The newest information relates to the very suppressed fact that SARS-CoV-2 Spike (in the universal covid injections) shares lot of amino acid homologies with HIV-1 gp160 protein (not only gp120!):

How much HIV is in SARS-CoV-2? Fauci's 2018 patent, the NEW Synthetic SARS-CoV-2 Spike gene, with the OLD content.

There is a cardiac glycoside drug named DIGOXIN, looking like this:

and inhibiting the Na⁺-K⁺-ATPase pump. Inhibition of the sodium-potassium-ATP pump, leads to increased intracellular calcium concentrations, resulting in after depolarizations and ventricular ectopic activity. Digoxin is derived from leaves of the digitalis plant (https://www.drugs.com/digoxin.html) and it is used to make the heart beat stronger with a more regular rhythm, it treats heart failure and is also used to treat atrial fibrillation, a heart rhythm disorder of the atria (the upper chambers of the heart that allow blood to flow into the heart). AND it is also connecting some dots in regard to HIV-1 integration into the human genome, explained more in this publication “Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation“^12. Here a quote from this work, indicating potential similarities to the action of SARS-CoV-2 (?):

“We confirmed that digoxin repressed viral gene expression by targeting the cellular Na⁺/K⁺ ATPase, but this did not explain its selectivity. Parallel RNAseq and integration mapping in infected cells demonstrated that digoxin inhibited expression of genes involved in T-cell activation and cell metabolism. Analysis of >400,000 unique integration sites showed that WT virus integrated more frequently than N74D mutant within or near genes susceptible to repression by digoxin and involved in T-cell activation and cell metabolism. Two main gene networks down-regulated by the drug were CD40L and CD38. Blocking CD40L by neutralizing antibodies selectively inhibited WT virus infection, phenocopying digoxin.“

The WT stands for ‘wild type’ of the HIV-1 virus..

Digoxin also interacts with the only BBB P-glycoprotein: https://www.pharmacytimes.com/view/2004-10-4618 , exactly like ivermectin, https://www.ncbi.nlm.nih.gov/books/NBK28180/ and many other brain targeting drugs like calcium channel blockers, cyclosporin, dabigatran etexilate, erythromycin, loperamide, protease inhibitors and tacrolimus (https://www.nps.org.au/australian-prescriber/articles/p-glycoprotein-and-its-role-in-drug-drug-interactions)

So it is all about chemical mimicry, replacement in which energy, defense mechanisms are changing, while cutting into the human DNA, changing it too.

And the word game, again, by adding just one letter ‘g’, is this all another pure coincidence??? The more HIV-1 plots, the more Fauci’s plots involved… But it is not only Fauci of course. Anyone loving wild life would be probably ready to put Zuckerberg and his wife Priscilla Chan right under a guillotine for all that what they done not only to wild animals: https://uncutnews.ch/100-millionen-tiere-wurden-bereits-die-mrna-technologie-injiziert-und-kaum-jemand-weiss-davon/ but equally to humans via their Chan Zuckerberg Biohub, all under the pretext of ‘helping humanity’, in particular via their IDseq DNA sequencing work…Just wonder, does China has it too?

The digoxin seems to be good against HIV-1 ^13, is dioxin good for anything???

This post will be expanded including the topic of light absorption by the aromatic compounds. In the meantime, please read carefully Steve’s post, before allowing to get boo(u)sted with synthetic genetic material which equally absorbs your precious photons and produces masses of toxic synthetics in your still natural body:

GAME OVER: Medicare data shows the COVID vaccines increase your chance of dying

Literature.

1. Kellie D. Nance and Jordan L. Meier* “Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines“ ACS Cent. Sci. 2021, 7, 5, 748–756. https://pubs.acs.org/doi/10.1021/acscentsci.1c00197

2. Hilary J Powers  ¹ , B M Corfe, E Nakano “Riboflavin in development and cell fate“ Subcell Biochem. 2012; 56: 229-45. doi: 10.1007/978-94-007-2199-9_12.

   2a. J. Warkany and E. Schraffenberger. “Congenital malformations induced in rats by maternal deficiency. V. Effects of a purified diet leaking riboflavin”Proc. Soc. Exp. Biol. Med. 54, 92-94. Reference from Thesis work by Margaret Louise Barrett titled ”Chemical evidence of the quantitative thiamin and riboflavin requirements of the rat during pregnancy and the development of the fetus” quote: “ The importance of riboflavin In the reproduction of rats has been forceably demonstrated by the work of Warkany et al. 1943,who have shown that insufficient riboflavin between the thirteenth and fifteenth days of pregnancy' resulted in an abnormal development of the skeleton of the embryo”.

3. M. Kamaraj,^a   J. Vijaya Sundar^a  and  V. Subramanian “Dioxin sensing properties of graphene and hexagonal boron nitride based van der Waals solids: a first-principles study†“ https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra18976h/unauth

4. https://www.nature.com/articles/nrd.2018.93

5. Andreas Wachter “Riboswitch-mediated control of gene expression
   in eukaryotes“ RNA Biology 7:1, 67-76; January/February 2010; © 2010 Landes Bioscience. https://www.tandfonline.com/doi/pdf/10.4161/rna.7.1.10489

6. Michael Banco, Marilee Ann Benore “Investigation of Riboflavin binding to DNA using polymerase chain reaction”. https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.27.1_supplement.975.6

7. Alan Poland and Edward Glover “An Estimate of the Maximum in Vivo Covalent Binding of 2,3,7,8-Tetrachlorodibenzo-p-dioxin to Rat Liver Protein, Ribosomal RNA, and DNA” CANCER RESEARCH 39, 3341 -3344, September 1979.

8. “Riboflavin Photosensitized Oxidation of 2,4-Dichlorophenol: Assessment of Possible Chlorinated Dioxin Formation” Jack R. Plimmer and Ute I. Klingebiel Science 22 Oct 1971 Vol 174, Issue 4007

   pp. 407-408 https://www.science.org/doi/10.1126/science.174.4007.407

9. R N Kurl, C A Villee “A metabolite of riboflavin binds to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) receptor“ Pharmacology. 1985;30(5):241-4. doi: 10.1159/000138073. https://pubmed.ncbi.nlm.nih.gov/2987979/

10. H L Monaco “Crystal structure of chicken riboflavin-binding protein” EMBO J. 1997 Apr 1;16(7):1475-83. doi: 10.1093/emboj/16.7.1475.

11. “Dioxin. Environmental Fate and Health/Ecological Consequences” book by Sudarshan Kurwadkar, Prabir K. Mandal and Shivani Soni. CRC 2020.

12. Alexander Zhyvoloup et al. “Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation“ July 20, 2017

    https://doi.org/10.1371/journal.ppat.1006460 and https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006460

13. Raymond W Wong  et al. “Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing“ PLoS Pathog. 2013 Mar;9(3):e1003241. doi: 10.1371/journal.ppat.1003241. Epub 2013 Mar 28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610647/pdf/ppat.1003241.pdf